Gamma Glutamyl Transferase - GGT

Gamma-glutamyltransferase (GGT) has been identified as a possible independent risk factor for cardiovascular death, according to an October 4 article in Circulation, a journal published by the American Heart Association. GGT is an enzyme that is present in the liver, blood, and also on the surface of many cells. A test for GGT levels is included in most panels to test liver function, as GGT levels are commonly elevated in alcohol abuse, or in other conditions affecting the liver.

This study used data from an analysis of 163,000 Austrian adults who were monitored over a course of 17 years. The analysis demonstrated a statistically significant link between elevated GGT and death from chronic forms of heart disease, stroke, and congestive heart failure. Interestingly, the link was strongest among adults younger than 60 years. There was also a link between acute heart attack and GGT in this group, but only among women.

Can GGT be confidently added to other serum markers for cardiovascular disease or mortality, such as C-reactive protein, homocysteine, lipid subfractions, or cholesterol? Further study is indicated. This study had some limitations noted by the authors. For example, the study population was predominately white. The authors refer to other studies that demonstrated possible ethnic differences in regard to elevated GGT, alcohol consumption and liver disease.

To purchase a GGT test, simply order online at LabSafe at http://www.labsafe.com/lab-tests/test/365/ or visit our website at www.labsafe.com

For more information, or to speak with a member of our Medical Staff, call LabSafe toll free at 1-888-333-LABS.